Indium(III) trifluoromethanesulfonate: An efficient reusable catalyst for the alkynylation-cyclization of 2-aminoaryl ketones and synthesis of 2,4-disubstituted quinolines

被引：57

作者：

Lekhok, Kushal C. ^{[1
]}

Prajapati, Dipak ^{[1
]}

Boruah, Ramesh C. ^{[1
]}

机构：

[1] NE Inst Sci & Technol, Dept Med Chem, Jorhat 785006, Assam, India

来源：

SYNLETT | 2008年 / 05期

关键词：

2,4-disubstituted quinolines; solvent-free conditions; microwave irradiations; indium triflate;

D O I：

10.1055/s-2008-1042800

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally friendly and highly efficient procedure for the preparation of 2,4-disubstituted quinoline derivatives has been developed by a simple alkynylation-cyclization reaction of 2-aminoaryl ketones with phenylacetylenes in the presence of indium(III) trifluoromethanesulfonate In(OTf)(3) under microwave irradiation and solvent-free conditions. This catalyst can be recovered after the reaction and reused efficiently in subsequent runs.

引用

页码：655 / 658

页数：4

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