Pathogenesis of rheumatoid arthritis: how early is early?

被引：22

作者：

Firestein, GS ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1186/ar1780

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Studies of cytokine expression in rheumatoid arthritis have provided key insights into the pathogenesis of disease and have offered clues for effective therapy. Patterns of T-cell products in chronic rheumatoid synovitis suggest that T helper type 1 cells contribute to the perpetuation of disease. However, there is no guarantee that the mechanisms of late disease are identical to very early rheumatoid arthritis. Evaluation of the cytokine profile at the earliest time points after onset of symptoms could identify novel targets that prevent progression to chronic arthritis.

引用

页码：157 / 159

页数：3

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