Isolation and characterization of the Haemophilus influenzae uvrA gene

被引：8

作者：

delaMorena, ML

Hendrixson, DR

StGeme, JW

机构：

[1] WASHINGTON UNIV,SCH MED,EDWARD MALLINCKRODT DEPT PEDIAT,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT MOL MICROBIOL,ST LOUIS,MO 63110

来源：

GENE | 1996年 / 177卷 / 1-2期

关键词：

DNA repair; DNA damage; excinuclease; nucleotide excision;

D O I：

10.1016/0378-1119(96)00264-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The uvr A gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvr A mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvrA was able to complement a mutation in the E. coli uvr A locus.

引用

页码：23 / 28

页数：6

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