The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

被引：125

作者：

Barrett, MP ^{[1
]}

Fairlamb, AH

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Dundee, Dept Biochem, Div Mol Parasitol & Biol Chem, Dundee DD1 4HN, Scotland

来源：

PARASITOLOGY TODAY | 1999年 / 15卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0169-4758(99)01414-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Resistance to currently used drugs is a serious problem in mast fields of antimicrobial chemotherapy. Crossresistance between two of the major classes of drug used irt the treatment of African trypanosomiasis, the melaminophenyl arsenicals and diamidines is easily selected in the laboratory. Here, Mike Barrett and Alan Fairlamb outline the mechanism underlying this crossresistance, which appears to arise as a result of alterations in an unusual adenosine transporter involved in the uptake of these drugs.

引用

页码：136 / 140

页数：5

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