Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis

被引：15

作者：

Cao, Renhai ^{[1
]}

Ji, Hong ^{[1
]}

Yang, Yunlong ^{[1
]}

Cao, Yihai ^{[1
,2
,3
,4
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[2] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden

[3] Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

[4] Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 03期

基金：

欧洲研究理事会;

关键词：

TNF-alpha; macrophage; inflammation; lymphangiogenesis; metastasis; LYMPHATIC METASTASIS; INDUCED ANGIOGENESIS;

D O I：

10.4161/2162402X.2014.989777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Although inflammation and metastasis are two well-known hallmarks of malignant disease, the relationship between inflammation and lymphatic metastasis is an unexplored research area. We recently elucidated a sophisticated mechanism by which TNF alpha-induced tumor inflammation conscripts macrophage-mediated VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.

引用

页码：1 / 3

页数：3

共 10 条

[1]

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis [J].

Cao, Renhai ;

Ji, Hong ;

Feng, Ninghan ;

Zhang, Yin ;

Yang, Xiaojuan ;

Andersson, Patrik ;

Sun, Yuping ;

Tritsaris, Katerina ;

Hansen, Anker Jon ;

Dissing, Steen ;

Cao, Yihai .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (39) :15894-15899

[2]

Mouse corneal lymphangiogenesis model [J].

Cao, Renhai ;

Lim, Sharon ;

Ji, Hong ;

Zhang, Yin ;

Yang, Yunlong ;

Honek, Jennifer ;

Hedlund, Eva-Maria ;

Cao, Yihai .

NATURE PROTOCOLS, 2011, 6 (06) :817-826

[3]

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis [J].

Cao, RH ;

Björndahl, MA ;

Religa, P ;

Clasper, S ;

Garvin, S ;

Galter, D ;

Meister, B ;

Ikomi, F ;

Tritsaris, K ;

Dissing, S ;

Ohhashi, T ;

Jackson, DG ;

Cao, YH .

CANCER CELL, 2004, 6 (04) :333-345

[4]

Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action [J].

Cao, RH ;

Björndahl, MA ;

Gallego, MI ;

Chen, SH ;

Religa, P ;

Hansen, AJ ;

Cao, YH .

BLOOD, 2006, 107 (09) :3531-3536

[5]

Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability [J].

Cao, RH ;

Eriksson, A ;

Kubo, H ;

Alitalo, K ;

Cao, YH ;

Thyberg, J .

CIRCULATION RESEARCH, 2004, 94 (05) :664-670

[6]

Opinion - Emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis [J].

Cao, YH .

NATURE REVIEWS CANCER, 2005, 5 (09) :735-743

[7]

Tumor-derived lymphangiogenic factors and lymphatic metastasis [J].

Cao, Yihai ;

Zhong, Weide .

BIOMEDICINE & PHARMACOTHERAPY, 2007, 61 (09) :534-539

[8]

Cao YH, 2009, FRONT BIOSCI-LANDMRK, V14, P3962, DOI [10.2735/3504, 10.2741/3504]

[9]

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling [J].

Ji, Hong ;

Cao, Renhai ;

Yang, Yunlong ;

Zhang, Yin ;

Iwamoto, Hideki ;

Lim, Sharon ;

Nakamura, Masaki ;

Andersson, Patrik ;

Wang, Jian ;

Sun, Yuping ;

Dissing, Steen ;

He, Xia ;

Yang, Xiaojuan ;

Cao, Yihai .

NATURE COMMUNICATIONS, 2014, 5

[10]

TUMOR-NECROSIS-FACTOR ALPHA-INDUCED ANGIOGENESIS DEPENDS ON IN-SITU PLATELET-ACTIVATING-FACTOR BIOSYNTHESIS [J].

MONTRUCCHIO, G ;

LUPIA, E ;

BATTAGLIA, E ;

PASSERINI, G ;

BUSSOLINO, F ;

EMANUELLI, G ;

CAMUSSI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :377-382

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