Tumor-derived lymphangiogenic factors and lymphatic metastasis

被引:25
作者
Cao, Yihai [1 ]
Zhong, Weide
机构
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Lab Angiogenesis Res, S-17177 Stockholm, Sweden
[2] Guangzhou Med Univ, Peoples Hosp 1, Guangzhou 510180, Guangdong, Peoples R China
关键词
lymphangiogenesis; angiogenesis; tumor growth; metastasis;
D O I
10.1016/j.biopha.2007.08.009
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Lymphatic endothelial cells (LECs) originally differentiated from venous endothelial cells express several specific makers that distinguish them from the blood vessels. Lymphangiogenesis, a complex process of sprouting of new lymphatic vessels, is regulated by multiple direct OF and indirect growth factors. Vascular endothelial growth factor-C (VEGF-C) is the most potent and selective lymphangiogenic factor that plays a crucial role in the establishment of the first lymphatic vessel during embryonic development and in mediating lymphatic metastasis. In addition to VEGF-C, recent studies show that a range of known tumor-produced angiogenic factors also stimulates lymphangiogenesis, suggesting complex and tight regulations of this process. These tumor-derived lymphangiogenic factors may either alone or jointly promote lymphatic metastasis. Understanding regulatory mechanisms of lymphangiogenesis is pivotal for development of lymphangiogenesis antagonists that might therapeutically be used for intervention of lymphatic metastasis. (C) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:534 / 539
页数:6
相关论文
共 55 条
  • [1] Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
    Achen, MG
    Jeltsch, M
    Kukk, E
    Mäkinen, T
    Vitali, A
    Wilks, AF
    Alitalo, K
    Stacker, SA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) : 548 - 553
  • [2] Focus on lymphangiogenesis in tumor metastasis
    Achen, MG
    McColl, BK
    Stacker, SA
    [J]. CANCER CELL, 2005, 7 (02) : 121 - 127
  • [3] Alitalo Kari, 2004, Cancer Res, V64, P9225, DOI 10.1158/0008-5472.CAN-04-2475
  • [4] Cancer and the chemokine network
    Balkwill, F
    [J]. NATURE REVIEWS CANCER, 2004, 4 (07) : 540 - 550
  • [5] Beasley NJP, 2002, CANCER RES, V62, P1315
  • [6] Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo
    Björndahl, M
    Cao, RH
    Nissen, LJ
    Clasper, S
    Johnson, LA
    Xue, Y
    Zhou, ZJ
    Jackson, D
    Hansen, AJ
    Cao, YH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (43) : 15593 - 15598
  • [7] Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
    Björndahl, MA
    Cao, R
    Burton, JB
    Brakenhielm, E
    Religa, P
    Galter, D
    Wu, L
    Cao, YH
    [J]. CANCER RESEARCH, 2005, 65 (20) : 9261 - 9268
  • [8] Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice
    Brantley-Sieders, Dana M.
    Fang, Wei Bin
    Hwang, Yoonha
    Hicks, Donna
    Chen, Jin
    [J]. CANCER RESEARCH, 2006, 66 (21) : 10315 - 10324
  • [9] PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    Cao, RH
    Björndahl, MA
    Religa, P
    Clasper, S
    Garvin, S
    Galter, D
    Meister, B
    Ikomi, F
    Tritsaris, K
    Dissing, S
    Ohhashi, T
    Jackson, DG
    Cao, YH
    [J]. CANCER CELL, 2004, 6 (04) : 333 - 345
  • [10] Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action
    Cao, RH
    Björndahl, MA
    Gallego, MI
    Chen, SH
    Religa, P
    Hansen, AJ
    Cao, YH
    [J]. BLOOD, 2006, 107 (09) : 3531 - 3536