Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid

被引：39

作者：

Assefa, H

Nimrod, A

Walker, L

Sindelar, R ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

基金：

美国农业部;

关键词：

D O I：

10.1016/S0960-894X(01)00210-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of oleanolic acid A/B-ring partial analogues was synthesized and tested for their complement inhibitory activity as well as cytotoxic properties. All target compounds and one intermediate exhibited moderate complement inhibitory potency. These compounds also showed cytotoxicity on malignant melanoma cell line, SK-MEL. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1619 / 1623

页数：5

共 24 条

[1]

[Anonymous], 1995, COMPLEMENT

[2] Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid [J].