The projected effect of risk factor reduction on Alzheimer's disease prevalence

被引：1979

作者：

Barnes, Deborah E. ^{[1
,4
]}

Yaffe, Kristine ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94121 USA

[4] San Francisco VA Med Ctr, San Francisco, CA USA

来源：

LANCET NEUROLOGY | 2011年 / 10卷 / 09期

关键词：

COGNITIVE IMPAIRMENT; PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS; INCIDENT DEMENTIA; VASCULAR-DISEASE; BLOOD-PRESSURE; GLOBAL BURDEN; MEDITERRANEAN DIET; METABOLIC SYNDROME; OLDER-ADULTS;

D O I：

10.1016/S1474-4422(11)70072-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

At present, about 33-9 million people worldwide have Alzheimer's disease (AD), and prevalence is expected to triple over the next 40 years. The aim of this Review was to summarise the evidence regarding seven potentially modifiable risk factors for AD: diabetes, midlife hypertension, midlife obesity, smoking, depression, cognitive inactivity or low educational attainment, and physical inactivity. Additionally, we projected the effect of risk factor reduction on AD prevalence by calculating population attributable risks (the percent of cases attributable to a given factor) and the number of AD cases that might be prevented by risk factor reductions of 10% and 25% worldwide and in the USA. Together, up to half of AD cases worldwide (17.2 million) and in the USA (2.9 million) are potentially attributable to these factors. A 10-25% reduction in all seven risk factors could potentially prevent as many as 1.1-3.0 million AD cases worldwide and 184000-492000 cases in the USA.

引用

页码：819 / 828

页数：10

共 101 条

[11] Physical activity and dementia: The need for prevention trials [J].