hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy

被引：142

作者：

Elyakim, Eran ^{[1
]}

Sitbon, Einat ^{[1
]}

Faerman, Alexander ^{[1
]}

Tabak, Sarit ^{[1
]}

Montia, Eve ^{[1
]}

Belanis, Liron ^{[1
]}

Dov, Avital ^{[1
]}

Marcusson, Eric G. ^{[3
]}

Bennett, C. Frank ^{[4
]}

Chajut, Ayelet ^{[1
]}

Cohen, Dalia ^{[2
]}

Yerushalmi, Noga ^{[1
]}

机构：

[1] Rosetta Genom Ltd, IL-76706 Rehovot, Israel

[2] Rosetta Genom Inc, Philadelphia, PA USA

[3] Regulus Therapeut, Carlsbad, CA USA

[4] Isis Pharmaceut Inc, Carlsbad, CA USA

来源：

CANCER RESEARCH | 2010年 / 70卷 / 20期

关键词：

ARYL-HYDROCARBON RECEPTOR; MICRORNA EXPRESSION; IN-VIVO; SUPPRESSOR GENE; AH RECEPTOR; CANCER; APOPTOSIS; GROWTH; LIVER; OVEREXPRESSION;

D O I：

10.1158/0008-5472.CAN-10-1313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hepatocellular carcinoma (HCC) is generally a fatal disease due to a paucity of effective treatment options. The identification of oncogenic microRNAs that exert pleiotropic effects in HCC cells may offer new therapeutic targets. In this study, we have identified the human microRNA miR-191 as a potential target for HCC therapy. Inhibition of miR-191 decreased cell proliferation and induced apoptosis in vitro and significantly reduced tumor masses in vivo in an orthotopic xenograft mouse model of HCC. Additionally, miR-191 was found to be upregulated by a dioxin, a known liver carcinogen, and was found to be a regulator of a variety of cancer-related pathways. Our findings offer a preclinical proof of concept for miR-191 targeting as a rational strategy to pursue for improving HCC treatment. Cancer Res; 70(20); 8077-87. (C) 2010 AACR.

引用

收藏

页码：8077 / 8087

页数：11

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