Hydroxymethylated cyclic α-amino acid dipeptides by ruthenium ring closing metathesis

被引：32

作者：

Hammer, K ^{[1
]}

Undheim, K ^{[1
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(98)00248-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Stereoselective syntheses of cyclic alpha-amino-beta-hydroxymethylcyclohexene-alpha-carboxylic acids are described. The acids were isolated as dipeptides. RCM reactions were effected by Ru(II)-catalysis on hydroxymethylated dienes. The diene substrates were available in stereochemically pure form by stepwise alkylations of (R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with 4-bromo-1-butene and vinyloxirane. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2359 / 2368

页数：10

共 19 条

[1]

Armstrong SK, 1998, J CHEM SOC PERK T 1, P371

[2] ASYMMETRIC TOTAL SYNTHESIS OF THE INDIVIDUAL DIASTEREOISOMERS OF HYPOGLYCIN-A [J].