Ruthenium-catalyzed enyne metathesis in stereoselective preparation of cyclic 1-amino-1-carboxylic acids.

被引：61

作者：

Hammer, K ^{[1
]}

Undheim, K ^{[1
]}

机构：

[1] UNIV OSLO, DEPT CHEM, N-0315 OSLO, NORWAY

来源：

TETRAHEDRON | 1997年 / 53卷 / 30期

关键词：

D O I：

10.1016/S0040-4020(97)00671-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective syntheses of alpha-amino acids are described. The alpha-carbon of the amino acid is incorporated into a five- or six-membered ring which is a conjugated diene with one exocyclic double bond. Enynes were intermediates for the metathesis cyclization reaction effected by ruthenium(II)-catalysis. The enyne substrates were available in stereochemically pure form by stepwise alkylations of the chiral auxiliary (R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with bromo-alkenes and -alkynes. (C) 1997 Elsevier Science Ltd.

引用

页码：10603 / 10614

页数：12

共 21 条

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