Peptidomimetic building blocks for drug discovery: An overview

被引：103

作者：

Goodman, M

Shao, H

机构：

[1] Department of Chemistry & Biochemistry, University of California, CA 92093-0343, U.S.A., San Diego La Jolla

来源：

PURE AND APPLIED CHEMISTRY | 1996年 / 68卷 / 06期

关键词：

D O I：

10.1351/pac199668061303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed new asymmetric and enantioselective routes for the preparation of a variety of conformationally constrained peptidomimetic building blocks. These molecules include cl-methylcysteine, alpha-methylthreonine, allo-threoninc, alpha,beta-dimethylcysteine, alpha,beta-dimethyltryptophan, twisted amide, and substituted lanthionine structures. It has been shown that these molecules are very useful building blocks for the peptidomimetic drug design.

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页码：1303 / 1308

页数：6

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