Scaling laws in the functional content of genomes

被引：217

作者：

van Nimwegen, E ^{[1
]}

机构：

[1] Rockefeller Univ, Ctr Studies Phys & Biol, New York, NY 12001 USA

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 09期

关键词：

D O I：

10.1016/S0168-9525(03)00203-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

With the number of sequenced genomes now totaling more than 100, and the availability of rough functional annotations for a substantial proportion of their genes, it has become possible to study the statistics of gene content across genomes. In this article I show that, for many high-level functional categories, the number of genes in each category scales as a power-law of the total number of genes in the genome. The occurrence of such scaling laws can be explained using a simple theoretical model, and this model suggests that the exponents of the observed scaling laws correspond to universal constants of the evolutionary process. I discuss some consequences of these scaling laws for our understanding of organism design.

引用

页码：479 / 484

页数：6

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