Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

被引：47

作者：

Lu, XY ^{[1
]}

Nicholson, JR ^{[1
]}

Akil, H ^{[1
]}

Watson, SJ ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA

来源：

NEUROREPORT | 2001年 / 12卷 / 06期

关键词：

Agouti-related protein (AGRP); dark cycle; food intake; light cycle;

D O I：

10.1097/00001756-200105080-00045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Agouti-related protein (AGRP) is a newly identified orexigenic peptide that acts as an endogenous antagonist of melanocortin receptors MC3 and MC4. The present study examined the time course of the orexigenic effects of synthetic AGRP (86-132). Intracerebroventricular infusion of 0.1 nmol AGRP (86-132) increased food intake by 450 +/- 81% at 2 h post-injection. A second increase in non-cumulative food intake (512 +/- 135%) was observed at 6 h post-injection. Following a single dose of AGRP (86-132) (0.1 nmol) the increased food intake was sustained for 6 days, occurring in the light cycle of the first 2 days and subsequently switching to the dark cycle of the last 4 days. These time course profiles indicate the complexity of the mechanisms involved in AGRP-induced feeding. NeuroReport 12:1281-1284 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1281 / 1284

页数：4

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