Expression of nitric oxide synthases in keratinocytes after UVB irradiation

被引：48

作者：

Chang, HR ^{[1
]}

Tsao, DA ^{[1
]}

Wang, SR ^{[1
]}

Yu, HS ^{[1
]}

机构：

[1] I Shou Univ, Dept Biomed Engn, Kaohsiung, Taiwan

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2003年 / 295卷 / 07期

关键词：

nitric oxide (NO); inducible nitric oxide synthase (iNOS); neuronal constitutive nitric oxide synthase (ncNOS); UVB;

D O I：

10.1007/s00403-003-0433-4

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The importance of nitric oxide (NO) in mediating vasodilation, neurotransmission, and immune and inflammatory responses has been demonstrated. Human keratinocyte express inducible nitric oxide synthase (iNOS) and the neuronal constitutive isoform of NOS (ncNOS). We established an in vitro model in keratinocytes to investigate changes in NO, iNOS and ncNOS expression after UVB exposure. We demonstrated a large induction of NO after UVB exposure and that the source of NO produced in UVB-exposed keratinocytes was increased expression of iNOS and ncNOS. The increased NO production with increased expression of iNOS and ncNOS may contribute to the pathological and physiological features of UVB-induced erythema and skin inflammation.

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收藏

页码：293 / 296

页数：4

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