Aging bone and cartilage: cross-cutting issues

被引：60

作者：

Carrington, JL ^{[1
]}

机构：

[1] NIA, Dept Hlth & Human Serv, Biol Aging Program, NIH, Bethesda, MD 20892 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 03期

关键词：

aging; cartilage; bone; osteoarthritis; osteoporosis; osteopenia; apoptosis; stem cells;

D O I：

10.1016/j.bbrc.2004.12.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is a major risk factor for osteoarthritis and osteoporosis. Yet, these are not necessary outcomes of aging, and the relationship between age-related changes in bone and cartilage and development of disease is not clear. There are some well-described cellular changes associated with aging in multiple tissues that appear to be fundamental to the decline in function of cartilage and bone. A better understanding of age-related changes in cells and tissues is necessary to mitigate or, hopefully, avoid loss of bone and cartilage with aging. In addition, a better understanding of the dynamics of tissue maintenance in vivo is critical to developing tissue replacement and repair therapies. The role of stem cells in this process, and why tissues are not well maintained with advancing age, are frontiers for future aging research. Published by Elsevier Inc.

引用

页码：700 / 708

页数：9