6-amino-2-(4-fluorophenyl)-4-methoxy-3(4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354):: A potent and selective p38 kinase inhibitor

被引：78

作者：

Henry, JR ^{[1
]}

Rupert, KC ^{[1
]}

Dodd, JH ^{[1
]}

Turchi, IJ ^{[1
]}

Wadsworth, SA ^{[1
]}

Cavender, DE ^{[1
]}

Fahmy, B ^{[1
]}

Olini, GC ^{[1
]}

Davis, JE ^{[1
]}

Pellegrino-Gensey, JL ^{[1
]}

Schafer, PH ^{[1
]}

Siekierka, JJ ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 22期

关键词：

D O I：

10.1021/jm980497b

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：4196 / 4198

页数：3

共 13 条

[1]

Badger AM, 1996, J PHARMACOL EXP THER, V279, P1453

[2] Cytokines in autoimmunity [J].

Brennan, FM ;

Feldmann, M .

CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (06) :872-877

[3] The future role of anti-tumour necrosis factor (TNF) products in the treatment of rheumatoid arthritis [J].

Camussi, G ;

Lupia, E .

DRUGS, 1998, 55 (05) :613-620

[4] Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinase [J].

Gallagher, TF ;

Seibel, GL ;

Kassis, S ;

Laydon, JT ;

Blumenthal, MJ ;

Lee, JC ;

Lee, D ;

Boehm, JC ;

FierThompson, SM ;

Abt, JW ;

Soreson, ME ;

Smietana, JM ;

Hall, RF ;

Garigipati, RS ;

Bender, PE ;

Erhard, KF ;

Krog, AJ ;

Hofmann, GA ;

Sheldrake, PL ;

McDonnell, PC ;

Kumar, S ;

Young, PR ;

Adams, JL .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (01) :49-64

[5] 2,4,5-TRIARYLIMIDAZOLE INHIBITORS OF IL-1 BIOSYNTHESIS [J].

GALLAGHER, TF ;

FIERTHOMPSON, SM ;

GARIGIPATI, RS ;

SORENSON, ME ;

SMIETANA, JM ;

LEE, D ;

BENDER, PE ;

LEE, JC ;

LAYDON, JT ;

GRISWOLD, DE ;

CHABOTFLETCHER, MC ;

BRETON, JJ ;

ADAMS, JL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (11) :1171-1176

[6] A MAP KINASE TARGETED BY ENDOTOXIN AND HYPEROSMOLARITY IN MAMMALIAN-CELLS [J].

HAN, J ;

LEE, JD ;

BIBBS, L ;

ULEVITCH, RJ .

SCIENCE, 1994, 265 (5173) :808-811

[7]

HENRY JR, 1998, IN PRESS TETRAHEDRON, V39

[8] Chemotactic peptide N-formyl-Met-Leu-Phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils [J].

Krump, E ;

Sanghera, JS ;

Pelech, SL ;

Furuya, W ;

Grinstein, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) :937-944

[9] A PROTEIN-KINASE INVOLVED IN THE REGULATION OF INFLAMMATORY CYTOKINE BIOSYNTHESIS [J].

LEE, JC ;

LAYDON, JT ;

MCDONNELL, PC ;

GALLAGHER, TF ;

KUMAR, S ;

GREEN, D ;

MCNULTY, D ;

BLUMENTHAL, MJ ;

HEYS, JR ;

LANDVATTER, SW ;

STRICKLER, JE ;

MCLAUGHLIN, MM ;

SIEMENS, IR ;

FISHER, SM ;

LIVI, GP ;

WHITE, JR ;

ADAMS, JL ;

YOUNG, PR .

NATURE, 1994, 372 (6508) :739-746

[10] SYNTHESIS AND BIOLOGICAL ACTIVITY OF SUBSTITUTED 2,6-DIAMINOPYRIDINES [J].

MARKEES, DG ;

DEWEY, VC ;

KIDDER, GW .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :126-&

← 1 2 →