Death begets failure in the heart

被引：236

作者：

Foo, RSY

Mani, K

Kitsis, RN

机构：

[1] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Cell Biol, Cardiovasc Res Ctr, Bronx, NY USA

[3] Albert Einstein Coll Med, Ctr Canc, Bronx, NY USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 03期

关键词：

D O I：

10.1172/JCI200524569

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recently, low - but abnormal - rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

引用

页码：565 / 571

页数：7

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