Solution and solid phase combinatorial synthesis of peptidomimetic library containing diversified α-methylated amino acids

被引：14

作者：

Kim, SW ^{[1
]}

Shin, YS ^{[1
]}

Ro, SG ^{[1
]}

机构：

[1] LG Chem Ltd, Biotech Res Inst, Taejon 305380, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00279-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A combinatorial peptidomimetic library containing diversified alpha-methylated amino acids was generated by the Ugi four component condensation (4cc) reaction from acids, amines, isocyanides and ketones in both solution and solid phase synthetic procedures. This one-pot methodology overall gave fair to good yields, which compare well with multi-step syntheses. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1665 / 1668

页数：4

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