DIASTEREOSELECTIVE ALKYLATION OF SULTAM-DERIVED AMINO-ACID ALDIMINES PREPARATION OF C-ALPHA-METHYLATED AMINO-ACIDS

被引：23

作者：

AYOUB, M ^{[1
]}

CHASSAING, G ^{[1
]}

LOFFET, A ^{[1
]}

LAVIELLE, S ^{[1
]}

机构：

[1] UNIV PARIS 06,CNRS,CHIM ORGAN BIOL LAB,F-75005 PARIS,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 23期

关键词：

D O I：

10.1016/0040-4039(95)00683-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of Schiff bases 2 derived from 4-chlorobenzaldehyde and sultam-derived amino acids 1 gave crystalline diastereomers 3 which after deprotection and re-crystallization, if necessary, afforded in good yield enantiomerically pure C alpha'-methylated amino acid (ex: alpha MePhe, alpha MeLeu, alpha MeMet).

引用

页码：4069 / 4072

页数：4

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