Theoretical Considerations of Tissue Electroporation With High-Frequency Bipolar Pulses

被引：100

作者：

Arena, Christopher B. ^{[1
]}

Sano, Michael B. ^{[1
]}

Rylander, Marissa Nichole ^{[2
]}

Davalos, Rafael V. ^{[1
]}

机构：

[1] Virginia Polytech & State Univ, Virginia Tech Wake Forest Sch Biomed Engn & Sci, Bioelectromech Syst Lab, Blacksburg, VA 24061 USA

[2] Virginia Polytech & State Univ, Virginia Tech Wake Forest Sch Biomed Engn & Sci, Virginia Tech Dept Mech Engn, Bioheat Transfer & Nanotherapeut Lab, Blacksburg, VA 24061 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2011年 / 58卷 / 05期

基金：

美国国家科学基金会;

关键词：

Bipolar pulses; electroporation; nanosecond pulsed electric field; oscillating electric field; transmembrane potential; CELL-MEMBRANE ELECTROPERMEABILIZATION; OSCILLATING ELECTRIC-FIELD; SOLID TUMOR TREATMENT; TIME-DOMAIN MODEL; IRREVERSIBLE ELECTROPORATION; DIELECTRIC-PROPERTIES; RECTANGULAR PULSES; ELECTROCHEMOTHERAPY; NANOSECOND; BREAKDOWN;

D O I：

10.1109/TBME.2010.2102021

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study introduces the use of high-frequency pulsed electric fields for tissue electroporation. Through the development of finite element models and the use of analytical techniques, electroporation with rectangular, bipolar pulses is investigated. The electric field and temperature distribution along with the associated transmembrane potential development are considered in a heterogeneous skin fold geometry. Results indicate that switching polarity on the nanosecond scale near the charging time of plasma membranes can greatly improve treatment outcomes in heterogeneous tissues. Specifically, high-frequency fields ranging from 500 kHz to 1 MHz are best suited to penetrate epithelial layers without inducing significant Joule heating, and cause electroporation in underlying cells.

引用

页码：1474 / 1482

页数：9

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