The S-phase checkpoint and its regulation in Saccharomyces cerevisiae

被引：57

作者：

Longhese, MP ^{[1
]}

Clerici, M ^{[1
]}

Lucchini, G ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dipartimento Biotecnol & Biosci, I-20126 Milan, Italy

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2003年 / 532卷 / 1-2期

关键词：

checkpoints; DNA damage; DNA repair; DNA replication;

D O I：

10.1016/j.mrfmmm.2003.08.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cells are never more vulnerable than during DNA replication, which represents a major moment of potential genetic instability. Genotoxic insults induce many different forms of DNA damage that may interfere with the ability of cells to properly duplicate their genome. Primary damage may in turn undergo structural transformations during DNA replication, thus generating secondary lesions that may be even more dangerous. Cells experiencing replication of damaged DNA or replication blocks activate an S-phase checkpoint response that assures the fidelity and completion of DNA replication before cells enter M-phase. The S-phase checkpoint pathway regulates not only progress through the cell cycle but also DNA repair and DNA replication itself. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：41 / 58

页数：18

共 153 条

[81] A role for DNA primase in coupling DNA replication to DNA damage response [J].