Risk Factors for Recurrence of Clostridium difficile Infection: Effect of Vancomycin-resistant Enterococci Colonization

被引：35

作者：

Choi, Hee Kyoung ^{[1
]}

Kim, Kye Hyung ^{[1
]}

Lee, Sun Hee ^{[1
]}

Lee, Su Jin ^{[1
]}

机构：

[1] Pusan Natl Univ, Sch Med, Med Res Inst, Dept Internal Med,Div Infect Dis, Pusan, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2011年 / 26卷 / 07期

关键词：

Clostridium difficile; Recurrence; Risk factors; VRE; ORAL METRONIDAZOLE; DIARRHEA; DISEASE; EPIDEMIOLOGY; CONTAMINATION; PROTECTION; OUTBREAK; COLITIS; FAECIUM;

D O I：

10.3346/jkms.2011.26.7.859

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recurrent Clostridium difficile infection (CDI) is one of the most difficult problems in healthcare infection control. We evaluated the risk factors associated with recurrence in patients with CDI. A retrospective cohort study of 84 patients with CDI from December 2008 through October 2010 was performed at Pusan National University Yangsan Hospital. Recurrence occurred in 13.1% (11/84) of the cases and in-hospital mortality rate was 7.1% (6/84). Stool colonization with vancomycin-resistant enterococci (VRE) (P = 0.006), exposure to more than 3 antibiotics (P = 0.009), low hemoglobin levels (P = 0.025) and continued use of previous antibiotics (P = 0.05) were found to be more frequent in the recurrent group. Multivariate analysis indicated that, stool VRE colonization was independently associated with CDI recurrence (odds ratio, 14.519; 95% confidence interval, 1.157-182.229; P = 0.038). This result suggests that stool VRE colonization is a significant risk factor for CDI recurrence.

引用

页码：859 / 864

页数：6

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