The sodium bile salt cotransport family SLC10

被引:208
作者
Hagenbuch, B [1 ]
Dawson, P
机构
[1] Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland
[2] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 447卷 / 05期
关键词
bile salt; enterohepatic circulation; NTCP; ASBT; liver; intestine; proximal tubule; cotransport;
D O I
10.1007/s00424-003-1130-z
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).
引用
收藏
页码:566 / 570
页数:5
相关论文
共 41 条
[1]   CPG ISLANDS OF THE X-CHROMOSOME ARE GENE ASSOCIATED [J].
ALCALAY, M ;
TONIOLO, D .
NUCLEIC ACIDS RESEARCH, 1988, 16 (20) :9527-9543
[2]   EXPRESSION AND CHARACTERIZATION OF A FUNCTIONAL-RAT LIVER NA+ BILE-ACID COTRANSPORT SYSTEM IN COS-7 CELLS [J].
BOYER, JL ;
NG, OC ;
ANANTHANARAYANAN, M ;
HOFMANN, AF ;
SCHTEINGART, CD ;
HAGENBUCH, B ;
STIEGER, B ;
MEIER, PJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (03) :G382-G387
[3]   Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver [J].
Cattori, V ;
Eckhardt, U ;
Hagenbuch, B .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1445 (01) :154-159
[4]   Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter [J].
Craddock, AL ;
Love, MW ;
Daniel, RW ;
Kirby, LC ;
Walters, HC ;
Wong, MH ;
Dawson, PA .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (01) :G157-G169
[5]   Sinusoidal (Basolateral) bile salt uptake systems of hepatocytes [J].
Hagenbuch, B ;
Meier, PJ .
SEMINARS IN LIVER DISEASE, 1996, 16 (02) :129-136
[6]   FUNCTIONAL EXPRESSION CLONING AND CHARACTERIZATION OF THE HEPATOCYTE NA+/BILE ACID COTRANSPORT SYSTEM [J].
HAGENBUCH, B ;
STIEGER, B ;
FOGUET, M ;
LUBBERT, H ;
MEIER, PJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10629-10633
[7]   MOLECULAR-CLONING, CHROMOSOMAL LOCALIZATION, AND FUNCTIONAL-CHARACTERIZATION OF A HUMAN LIVER NA+ BILE-ACID COTRANSPORTER [J].
HAGENBUCH, B ;
MEIER, PJ .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1326-1331
[8]   Inhibition of the human sodium/bile acid cotransporters by side-specific methanethiosulfonate sulfhydryl reagents:: Substrate-controlled accessibility of site of inactivation [J].
Hallén, S ;
Fryklund, J ;
Sachs, G .
BIOCHEMISTRY, 2000, 39 (22) :6743-6750
[9]   Membrane insertion scanning of the human ileal sodium/bile acid co-transporter [J].
Hallén, S ;
Brändén, M ;
Dawson, PA ;
Sachs, G .
BIOCHEMISTRY, 1999, 38 (35) :11379-11388
[10]   Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor [J].
Hallén, S ;
Björquist, A ;
Östlund-Lindqvist, AM ;
Sachs, G .
BIOCHEMISTRY, 2002, 41 (50) :14916-14924