The sodium bile salt cotransport family SLC10

被引：211

作者：

Hagenbuch, B ^{[1
]}

Dawson, P

机构：

[1] Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland

[2] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 447卷 / 05期

关键词：

bile salt; enterohepatic circulation; NTCP; ASBT; liver; intestine; proximal tubule; cotransport;

D O I：

10.1007/s00424-003-1130-z

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

引用

页码：566 / 570

页数：5

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