Towards a computational reconstruction of the electrodynamics of premature and full term human labour

被引：27

作者：

Aslanidi, O. V. ^{[2
]}

Atia, J. ^{[3
]}

Benson, A. P. ^{[1
]}

van den Berg, H. A. ^{[4
]}

Blanks, A. M. ^{[3
]}

Choi, C. ^{[2
]}

Gilbert, S. H. ^{[1
]}

Goryanin, I. ^{[5
]}

Hayes-Gill, B. R. ^{[6
]}

Holden, A. V. ^{[1
]}

Li, P. ^{[7
]}

Norman, J. E. ^{[8
]}

Shmygol, A. ^{[3
]}

Simpson, N. A. B. ^{[9
]}

Taggart, M. J. ^{[10
]}

Tong, W. C. ^{[10
]}

Zhang, H. ^{[2
]}

机构：

[1] Univ Leeds, Inst Membrane & Syst Biol, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Manchester, Biol Phys Grp, Sch Phys & Astron, Manchester M13 9PL, Lancs, England

[3] Univ Warwick, Clin Sci Res Inst, Univ Hosp Coventry & Warwickshire, Warwick Med Sch, Warwick CV2 2DX, England

[4] Univ Warwick, Warwick Syst Biol Ctr, Coventry CV4 7AL, W Midlands, England

[5] Univ Edinburgh, Sch Informat, Edinburgh EH8 9YL, Midlothian, Scotland

[6] Univ Nottingham, Dept Elect Engn, Nottingham NG7 RD, England

[7] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[8] Univ Edinburgh, MRC Ctr Reprod Hlth, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

[9] Leeds Gen Infirm, Leeds LS1 3EX, W Yorkshire, England

[10] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2011年 / 107卷 / 01期

基金：

英国医学研究理事会;

关键词：

Uterine; Smooth muscle; Physiome; Electrophysiology; Mathematical modelling; DIFFUSION-TENSOR MRI; SMOOTH-MUSCLE-CELLS; PREGNANT RAT UTERUS; HUMAN MYOMETRIUM; UTERINE CONTRACTIONS; ELECTRICAL-ACTIVITY; MAGNETOMYOGRAPHIC RECORDINGS; HISTOLOGICAL VALIDATION; EXCITATION-CONTRACTION; K+ CHANNELS;

D O I：

10.1016/j.pbiomolbio.2011.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：183 / 192

页数：10

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