Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

被引:523
作者
Mogil, JS
Wilson, SG
Bon, K
Lee, SE
Chung, K
Raber, P
Pieper, JO
Hain, HS
Belknap, JK
Hubert, L
Elmer, GI
Chung, JM
Devor, M
机构
[1] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA
[2] Univ Illinois, Neurosci Program, Champaign, IL 61820 USA
[3] Univ Texas, Med Branch, Inst Marine Biomed, Galveston, TX 77555 USA
[4] Univ Texas, Med Branch, Dept Anat & Neurosci, Galveston, TX 77555 USA
[5] Hebrew Univ Jerusalem, Inst Life Sci, Dept Cell & Anim Biol, IL-91904 Jerusalem, Israel
[6] NIDA, Behav Neurosci Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA
[7] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA
[8] Oregon Hlth & Sci Univ, VA Med Ctr, Portland, OR 97201 USA
[9] Univ Maryland Baltimore Cty, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA
关键词
algesiometry; inbred strains; mouse genetics; pain models; strain differences;
D O I
10.1016/S0304-3959(98)00197-3
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
It is generally acknowledged that humans display highly variable sensitivity to pain, including variable responses to identical injuries or pathologies, The possible contribution of genetic factors has, however, been largely overlooked. An emerging rodent literature documents the importance of genotype in mediating basal nociceptive sensitivity, in establishing a predisposition to neuropathic pain following neural injury, and in determining sensitivity to pharmacological agents and endogenous antinociception. One clear finding from these studies is that the effect of genotype is at least partially specific to the nociceptive assay being considered. In this report we begin to systematically describe and characterize genetic variability of nociception in a mammalian species, Mus musculus. We tested 11 readily-available inbred mouse strains (129/J, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, C58/J, CBA/J, DBA/2J, RIIIS/J and SM/J) using 12 common measures of nociception. These included assays for thermal nociception (hot plate, Hargreaves' test, tail withdrawal), mechanical nociception (von Frey filaments), chemical nociception (abdominal constriction, carrageenan, formalin), and neuropathic pain (autotomy, Chung model peripheral nerve injury). We demonstrate the existence of clear strain differences in each assay, with 1.2 to 54-fold ranges of sensitivity. All nociceptive assays display moderate-to-high heritability (h(2) = 0.30-0.76) and mediation by a limited number of apparent genetic loci. Data comparing inbred strains have considerable utility as a tool for understanding the genetics of nociception, and a particular relevance to transgenic studies. (C) 1999 international Association for the Study of Pain. Published by Elsevier Science B.V.
引用
收藏
页码:67 / 82
页数:16
相关论文
共 111 条
[1]   THE STRESS OF A NOVEL ENVIRONMENT REDUCES FORMALIN PAIN - POSSIBLE ROLE OF SEROTONIN [J].
ABBOTT, FV ;
FRANKLIN, KBJ ;
CONNELL, B .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 126 (1-2) :141-144
[2]   BEHAVIORAL-EFFECTS OF DIFFERENT INTENSITIES OF FORMALIN PAIN IN RATS [J].
ALOISI, AM ;
ALBONETTI, ME ;
CARLI, G .
PHYSIOLOGY & BEHAVIOR, 1995, 58 (03) :603-610
[3]  
[Anonymous], APS J
[4]  
[Anonymous], [No title captured]
[5]   GENE TREES AND THE ORIGINS OF INBRED STRAINS OF MICE [J].
ATCHLEY, WR ;
FITCH, WM .
SCIENCE, 1991, 254 (5031) :554-558
[6]   INDIVIDUAL PAIN HISTORY AND FAMILIAL PAIN TOLERANCE MODELS - RELATIONSHIPS TO POSTSURGICAL PAIN [J].
BACHIOCCO, V ;
SCESI, M ;
MORSELLI, AM ;
CARLI, G .
CLINICAL JOURNAL OF PAIN, 1993, 9 (04) :266-271
[7]   SIMILARITIES IN DEGENERATIVE FINDINGS ON MAGNETIC-RESONANCE IMAGES OF THE LUMBAR SPINES OF IDENTICAL-TWINS [J].
BATTIE, MC ;
HAYNOR, DR ;
FISHER, LD ;
GILL, K ;
GIBBONS, LE .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1995, 77A (11) :1662-1670
[8]   PAIN IN MEN WOUNDED IN BATTLE [J].
BEECHER, HK .
ANNALS OF SURGERY, 1946, 123 (01) :96-105
[9]   CHROMOSOME MAPPING OF GENE LOCI AFFECTING MORPHINE AND AMPHETAMINE RESPONSES IN BXD RECOMBINANT INBRED MICE [J].
BELKNAP, JK ;
CRABBE, JC .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 654 :311-323
[10]   LOCALIZATION TO CHROMOSOME-10 OF A LOCUS INFLUENCING MORPHINE ANALGESIA IN CROSSES DERIVED FROM C57BL/6 AND DBA/2 STRAINS [J].
BELKNAP, JK ;
MOGIL, JS ;
HELMS, ML ;
RICHARDS, SP ;
OTOOLE, LA ;
BERGESON, SE ;
BUCK, KJ .
LIFE SCIENCES, 1995, 57 (10) :PL117-PL124