Multiple roles for DNA methylation in gametic imprinting

被引：54

作者：

Neumann, B ^{[1
]}

Barlow, DP ^{[1
]}

机构：

[1] INST MOLEC PATHOL,A-1030 VIENNA,AUSTRIA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(96)80045-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Allele-specific DNA methylation has been observed for all tested imprinted genes and has a clear role in the imprinting mechanism. It remains to be resolved whether this role is to act as the gametic imprinting signal or to cause or maintain allele-specific expression.

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收藏

页码：159 / 163

页数：5

相关论文

共 45 条

[1] GAMETE-SPECIFIC METHYLATION CORRELATES WITH IMPRINTING OF THE MURINE XIST GENE [J].

ARIEL, M ;

ROBINSON, E ;

MCCARREY, JR ;

CEDAR, H .

NATURE GENETICS, 1995, 9 (03) :312-315

[2] GAMETIC IMPRINTING IN MAMMALS [J].

BARLOW, DP .

SCIENCE, 1995, 270 (5242) :1610-1613

[3] LOSS OF METHYLATION ACTIVATES XIST IN SOMATIC BUT NOT IN EMBRYONIC-CELLS [J].

BEARD, C ;

LI, E ;

JAENISCH, R .

GENES & DEVELOPMENT, 1995, 9 (19) :2325-2334

[4] DNA METHYLTRANSFERASES [J].

BESTOR, TH ;

VERDINE, GL .

CURRENT OPINION IN CELL BIOLOGY, 1994, 6 (03) :380-389

[5] SP1 ELEMENTS PROTECT A CPG ISLAND FROM DE-NOVO METHYLATION [J].

BRANDEIS, M ;

FRANK, D ;

KESHET, I ;

SIEGFRIED, Z ;

MENDELSOHN, M ;

NEMES, A ;

TEMPER, V ;

RAZIN, A ;

CEDAR, H .

NATURE, 1994, 371 (6496) :435-438

[6] INHERITED MICRODELETIONS IN THE ANGELMAN AND PRADER-WILLI SYNDROMES DEFINE AN IMPRINTING CENTER ON HUMAN-CHROMOSOME-15 [J].

BUITING, K ;

SAITOH, S ;

GROSS, S ;

DITTRICH, B ;

SCHWARTZ, S ;

NICHOLLS, RD ;

HORSTHEMKE, B .

NATURE GENETICS, 1995, 9 (04) :395-400

[7] REGULATION OF GENOMIC IMPRINTING BY GAMETIC AND EMBRYONIC PROCESSES [J].

CHAILLET, JR ;

BADER, DS ;

LEDER, P .

GENES & DEVELOPMENT, 1995, 9 (10) :1177-1187

[8]

CLARK J, 1995, NAT GENET, V10, P20

[9] CPG ISLANDS AND GENES [J].

CROSS, SH ;

BIRD, AP .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1995, 5 (03) :309-314

[10] TISSUE-SPECIFIC AND DEVELOPMENTAL STAGE-SPECIFIC IMPRINTING OF THE MOUSE PROINSULIN GENE, INS2 [J].

DELTOUR, L ;

MONTAGUTELLI, X ;

GUENET, JL ;

JAMI, J ;

PALDI, A .

DEVELOPMENTAL BIOLOGY, 1995, 168 (02) :686-688

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