The ISG56/IFIT1 Gene Family

被引：237

作者：

Fensterl, Volker ^{[1
]}

Sen, Ganes C. ^{[1
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Mol Genet, Cleveland, OH 44195 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2011年 / 31卷 / 01期

关键词：

INTERFERON-STIMULATED GENES; INDUCIBLE HUMAN GENES; DOUBLE-STRANDED-RNA; MOLECULAR-CLONING; EUKARYOTIC INITIATION-FACTOR-3; TRANSLATION INITIATION; REGULATORY FACTOR-3; VIRUS-INFECTION; INDUCED PROTEIN; MESSENGER-RNA;

D O I：

10.1089/jir.2010.0101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ISG56/IFIT1 family of genes is clustered on human chromosome 10 and is comprised of 4 members, ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, and ISG58/IFIT5, whose homologs are evolutionarily conserved from mammals to amphibians. While these genes are normally silent in most cell types, their transcription is strongly induced by interferons, virus infection, and molecular patterns such as double-stranded RNA or lipopolysaccharides. The encoded P56 family proteins are characterized by multiple repeats of tetratricopeptide repeat helix-turn-helix motifs mediating a variety of protein-protein interactions, which result in a multitude of effects on cellular and viral functions, such as translation initiation, virus replication, double-stranded RNA signaling, cell migration, and proliferation.

引用

页码：71 / 78

页数：8

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