Impairment of respiratory muscle function in pulmonary hypertension

被引：64

作者：

Kabitz, Hans-Joachim ^{[1
]}

Schwoerer, Anja ^{[1
]}

Bremer, Hinrich-Cordt ^{[1
]}

Sonntag, Florian ^{[1
]}

Walterspacher, Stephan ^{[1
]}

Walker, David ^{[1
]}

Schaefer, Vanessa ^{[2
]}

Ehlken, Nicola ^{[2
]}

Staehler, Gerd ^{[3
]}

Halank, Michael ^{[4
]}

Klose, Hans ^{[5
]}

Ghofrani, Hossein A. ^{[6
]}

Hoeper, Marius M. ^{[7
]}

Gruenig, Ekkehard ^{[2
]}

Windisch, Wolfram ^{[1
]}

机构：

[1] Univ Hosp Freiburg, Dept Pneumol, D-79106 Freiburg, Germany

[2] Univ Heidelberg Hosp, Dept Cardiol & Pneumol, D-69120 Heidelberg, Germany

[3] Loewenstein Hosp & Rehabil Ctr, Dept Pneumol & Cardiol, D-74245 Loewenstein, Germany

[4] Univ Hosp Dresden, Dept Internal Med 1, D-01307 Dresden, Germany

[5] Univ Hosp Hamburg Eppendorf, Dept Pneumol, D-20246 Hamburg, Germany

[6] Univ Hosp Giessen, Dept Pneumol, D-35392 Giessen, Germany

[7] Hannover Med Sch, Dept Pneumol, D-30625 Hannover, Germany

来源：

CLINICAL SCIENCE | 2008年 / 114卷 / 1-2期

关键词：

exercise; lung function; pulmonary heart disease; pulmonary hypertension; respiratory muscle strength; twitch pressure;

D O I：

10.1042/CS20070238

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been suggested that impaired respiratory muscle function occurs in patients with PH (pulmonary hypertension); however, comprehensive investigations of respiratory muscle function, including the application of non-volitional tests, needed to verify impairment of respiratory muscle strength in patients with PH have not yet been performed. In the present study, respiratory muscle function was assessed in 31 patients with PH (20 females and 11 males; mean pulmonary artery pressure, 51 +/- 20 mmHg; median World Health Organization class 3.0 +/- 0.5; 25 patients with pulmonary arterial hypertension and six patients with chronic thromboembolic PH) and in 31 control subjects (20 females and I I males) well-matched for gender, age and BMI (body mass index). A 6-min walking test was performed to determine exercise capacity. Volitionally assessed maximal inspiratory (7.5 +/- 2.1 compared with 6.2 +/- 2.8 kPa; P = 0.04) and expiratory (13.3 +/- 4.2 compared with 9.9 +/- 3.4 kPa; P < 0.001) mouth pressures, sniff nasal (8.3 +/- 1.9 compared with 6.6 +/- 2.2 kPa; P = 0.002) and transdiaphragmatic (11.3 +/- 2.5 compared with 8.7 +/- 2.5 kPa.; P < 0.00 1) pressures, non-volitionally assessed twitch mouth (1.46 +/- 0.43 compared with 0.97 +/- 0.41 kPa; P < 0.00 1) and transdiaphragmatic (2.08 +/- 0.55 compared with 1.47 +/- 0.72 kPa; P = 0.00 1) pressures during bilateral anterior magnetic phrenic nerve stimulation were markedly lower in patients with PH compared with control subjects. Maximal inspiratory mouth (r = 0.58, P < 0.00 1) and sniff transdiaphragmatic (r = 0.43, P = 0.02) pressures were correlated with the 6-min walking distance in patients with PH. In conclusion, the present study provides strong evidence that respiratory muscle: strength is reduced in patients with PH compared with well-matched control subjects. Furthermore, the 6-min walking distance is significantly linked to parameters assessing inspiratory muscle strength.

引用

页码：165 / 171

页数：7