Nickel- and palladium-catalyzed cross-coupling reaction of polyfluorinated arenes and alkenes with Grignard reagents

被引：109

作者：

Saeki, T ^{[1
]}

Takashima, Y ^{[1
]}

Tamao, K ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Int Res Ctr Elements Sci, Kyoto 6110011, Japan

来源：

SYNLETT | 2005年 / 11期

关键词：

cross-coupling; nickel; palladium; Grignard reagent; fluoroarene;

D O I：

10.1055/s-2005-871571

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cross-coupling reaction of fluorobenzene with an aryl Grignard reagent has been reinvestigated which revealed that the reaction readily proceeds under ordinary conditions using a catalytic amount of NiCl2(dppp) even at room temperature. The use of nickel catalysts and Grignard reagent is essential for the activation of the carbon-fluorine bond. The palladium catalyst is also effective for the 1,2-difluorobenzene and trifluorobenzenes to selectively produce the corresponding mono-coupled products while the nickel-based catalyst system affords a mixture of the mono-coupled product and di- or tri-coupled product.

引用

页码：1771 / 1774

页数：4

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