Plasmapheresis May Be an Option in Urgent Management of Heparin-Induced Thrombocytopenia in the Setting of Acute Intracerebral Hemorrhage

被引：16

作者：

Iluonakhamhe, Emitseilu ^{[1
]}

Ibekwe, Oluchukwu ^{[1
]}

Samuel, Sophie ^{[1
]}

Zakaria, Asma ^{[1
]}

机构：

[1] UT Houston Med Ctr, Houston, TX 77030 USA

来源：

NEUROCRITICAL CARE | 2015年 / 22卷 / 01期

关键词：

Plasmapheresis; Heparin-induced thrombocytopenia; Heparin antibody enzyme-linked immunosorbent assay; Heparin-induced platelet aggregation; OPTICAL-DENSITY VALUES; THROMBOSIS; DIAGNOSIS; ELISA;

D O I：

10.1007/s12028-014-0052-2

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

We report a case of heparin-induced thrombocytopenia (HIT) that was complicated by acute intracerebral hemorrhage (ICH) and bilateral adrenal hemorrhage. In the setting of worsening thrombocytopenia, the risk of expansion of ICH and additional thrombotic events is concerning; hence, we employed plasmapheresis to reduce thrombotic risk. We followed serial daily heparin antibody enzyme-linked immunosorbent assay (ELISA) optical density measurements as well as heparin-induced platelet aggregation (HIPA) assays on both pre- and post-pheresis samples in order to objectively determine when thrombotic risk was sufficiently decreased. After four cycles of plasmapheresis, both heparin antibody ELISA and HIPA assays became negative. This case helps illustrate the utility of plasmapheresis in management of HIT when anticoagulation is contraindicated.

引用

页码：140 / 145

页数：6

共 17 条

[1]

Heparin-induced thrombocytopenia [J].