The aging of the retina

被引：57

作者：

Bonnel, S

Mohand-Said, S

Sahel, JA

机构：

[1] Ctr Hosp Natl Ophthalmol Quinze Vingts, F-75012 Paris, France

[2] INSERM, U592, F-75654 Paris 13, France

来源：

EXPERIMENTAL GERONTOLOGY | 2003年 / 38卷 / 08期

关键词：

age-related; retina; macular area;

D O I：

10.1016/S0531-5565(03)00093-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

This mini-review summarizes our current knowledge concerning the age-related changes that affect the retina. Over the last 10 years, our understanding of the genetics of hereditary retinal diseases has improved considerably. However, the modifications that occur in the retina as a result of aging are still under investigation. In this review, we place particular emphasis on the normal retinal alterations that occur with aging (gene modulation; psychophysical, structural and cellular alterations). We describe the events that occur during the pathological aging process, such as in age-related macular degeneration. Understanding these different modifications is essential if we are to find key players on which to base therapeutic interventions that may help to prevent the passage of normal aging process to the pathological aging process. (C) 2003 Elsevier Inc. All rights reserved.

引用

收藏

页码：825 / 831

页数：7

相关论文

共 51 条

[31] Ocular neovascularization: An epidemiologic review [J].

Lee, P ;

Wang, CC ;

Adamis, AP .

SURVEY OF OPHTHALMOLOGY, 1998, 43 (03) :245-269

[32] Proteasome function and protein oxidation in the aged retina [J].

Louie, JL ;

Kapphahn, RJ ;

Ferrington, DA .

EXPERIMENTAL EYE RESEARCH, 2002, 75 (03) :271-284

[33]

Medeiros NE, 2001, INVEST OPHTH VIS SCI, V42, P795

[34] Selective transplantation of rods delays cone loss in a retinitis pigmentosa model [J].

Mohand-Said, S ;

Hicks, D ;

Dreyfus, H ;

Sahel, JA .

ARCHIVES OF OPHTHALMOLOGY, 2000, 118 (06) :807-811

[35] Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse [J].

Mohand-Said, S ;

Deudon-Combe, A ;

Hicks, D ;

Simonutti, M ;

Forster, V ;

Fintz, AC ;

Leveillard, T ;

Dreyfus, H ;

Sahel, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8357-8362

[36] Rod-cone interactions:: Developmental and clinical significance [J].

Mohand-Said, S ;

Hicks, D ;

Léveillard, T ;

Picaud, S ;

Porto, F ;

Sahel, JA .

PROGRESS IN RETINAL AND EYE RESEARCH, 2001, 20 (04) :451-467

[37] Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease [J].

Mullins, RF ;

Russell, SR ;

Anderson, DH ;

Hageman, GS .

FASEB JOURNAL, 2000, 14 (07) :835-846

[38]

Owsley C, 2000, INVEST OPHTH VIS SCI, V41, P267

[39] Delays in rod-mediated dark adaptation in early age-related maculopathy [J].

Owsley, C ;

Jackson, GR ;

White, M ;

Feist, R ;

Edwards, D .

OPHTHALMOLOGY, 2001, 108 (07) :1196-1202

[40] Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa [J].

Petters, RM ;

Alexander, CA ;

Wells, KD ;

Collins, EB ;

Sommer, JR ;

Blanton, MR ;

Rojas, G ;

Hao, Y ;

Flowers, WL ;

Banin, E ;

Cideciyan, AV ;

Jacobson, SG ;

Wong, F .

NATURE BIOTECHNOLOGY, 1997, 15 (10) :965-970

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