Antiaggregant and anticoagulant therapy in systemic lupus erythematosus and Hughes' syndrome

被引：24

作者：

Ruiz-Irastorza, G

Khamashta, MA ^{[1
]}

Hughes, GRV

机构：

[1] St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7RH, England

[2] Hosp Mendaro, Serv Internal Med, Gipuzkoa, Spain

来源：

LUPUS | 2001年 / 10卷 / 03期

关键词：

antiphospholipid; aspirin; heparin; miscarriage; thrombosis; warfarin;

D O I：

10.1191/096120301667789546

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiaggregant and anticoagulant drugs are essential in the management of the manifestations due to antiphospholipid syndrome (APS) in patients with primary Hughes' syndrome or systemic lupus erythematosus. Coumadin derivatives (warfarin and acenocumarol), heparin and aspirin are used for secondary thromboprophylaxis and treatment of recurrent miscarriage. The available evidence for each indication is reviewed in this paper. There is still debate regarding the optimal intensity of oral anticoagulation, the best drug combination for pregnancy failure in APS and the management of asymptomatic patients with antiphospholipid antibodies.

引用

页码：241 / 245

页数：5

共 49 条

[1]

BRANCH DW, 1992, OBSTET GYNECOL, V80, P614

[2] A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy [J].