Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone

被引：37

作者：

Costedoat-Chalumeau, N ^{[1
]}

Amoura, Z ^{[1
]}

Aymard, G ^{[1
]}

Sevin, O ^{[1
]}

Wechsler, B ^{[1
]}

Cacoub, P ^{[1
]}

Du, LTH ^{[1
]}

Diquet, B ^{[1
]}

Ankri, A ^{[1
]}

Piette, JC ^{[1
]}

机构：

[1] Grp Hosp Univ Pitie Salpetriere, Paris, France

来源：

ANNALS OF INTERNAL MEDICINE | 2000年 / 132卷 / 08期

关键词：

D O I：

10.7326/0003-4819-132-8-200004180-00005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Oral anticoagulants and pulse high-dose intravenous methylprednisolone are often administered concomitantly, but no data on potential interactions are available. Objective: To assess possible potentiation of oral anticoagulation by high-dose intravenous methylprednisolone. Design: Prospective cohort study. Setting: University hospital in Paris, France. Patients: 10 consecutive patients concomitantly receiving methylprednisolone and oral anticoagulants (fluindione and acenocoumarol) and 5 consecutive controls receiving methylprednisolone alone. Measurements: Serial determinations of the international normalized ratio (INR) and clotting factors during administration of pulse methylprednisolone. The total plasma fluindione concentration was determined in 3 patients. Results: The mean INR was 2.75 (range, 2.02 to 3.81) at baseline and increased to 8.04 (range, 5.32 to 20.0) after methylprednisolone administration. Plasma fluindione concentrations and the INR increased after methylprednisolone administration. Methylprednisolone alone did not increase prothrombin time. Conclusions: The action of oral anticoagulants is potentiated by intravenous high-dose methylprednisolone. The INR should be monitored daily during concomitant administration of these medications.

引用

页码：631 / 635

页数：5

共 18 条

[1] Rapid and simple micromethod for the quantification of fluindione in human plasma using high-performance liquid chromatography [J].