Interleukin-1β and adverse effects on cerebral blood flow during long-term global hypoperfusion

被引:24
作者
Maher, CO
Anderson, RE
Martin, HS
McClelland, RL
Meyer, FB
机构
[1] Mayo Clin, Dept Neurol Surg, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Neurosurg & Biostat, Cerebrovasc Res Lab, Rochester, MN 55905 USA
关键词
cerebral blood flow; cytokine; interleukin-1; beta; rat;
D O I
10.3171/jns.2003.99.5.0907
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Object. The effects of interleukin (IL)-1beta on the cerebral vasculature are complex and incompletely understood. Many pathophysiological states in which inflammatory cascades have been implicated also have varying degrees of cerebral hypoperfusion. The purpose of this investigation was to examine the long-term effects of this proinflammatory cytokine and its antagonist on cerebral blood flow (CBF) following global cerebral hypoperfusion. Methods. Sprague-Dawley rats were randomly assigned to 12 groups and given continuous intracerebroventricular (ICV) infusions of IL-1beta, the IL-1 receptor antagonist (IL-1ra), or saline vehicle (control). Global cerebral hypoperfusion was produced by occlusion of both carotid arteries and one vertebral artery. Cerebral blood flow was measured at baseline and again after initiation of the infusions by performing a Xe-133 clearance study. Prolonged ICV administration of IL-1beta resulted in a significant decrease in CBF compared with that in controls. Prolonged administration of the antagonist IL-1ra resulted in significant increases in CBF compared with that in both IL-1beta-treated animals and controls. Conclusions. This experiment demonstrates that long-term treatment with the proinflammatory cytokine IL-1beta adversely affects CBF.
引用
收藏
页码:907 / 912
页数:6
相关论文
共 67 条
[51]   Tumor necrosis factor-alpha induces pial arteriolar dilation in newborn pigs [J].
Shibata, M ;
Parfenova, H ;
Zuckerman, SL ;
Leffler, CW .
BRAIN RESEARCH BULLETIN, 1996, 39 (04) :241-247
[52]   Interleukin-1 beta peptides induce cerebral pial arteriolar dilation in anesthetized newborn pigs [J].
Shibata, M ;
Parfenova, H ;
Zuckerman, SL ;
Seyer, JM ;
Krueger, JM ;
Leffler, CW .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1996, 270 (05) :R1044-R1050
[53]   Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo - The role of platelet-derived growth factor [J].
Shimokawa, H ;
Ito, A ;
Fukumoto, Y ;
Kadokami, T ;
Nakaike, R ;
Sakata, M ;
Takayanagi, T ;
Egashira, K ;
Takeshita, A .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (03) :769-776
[54]   Experimental closed head injury: Analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines [J].
Stahel, PF ;
Shohami, E ;
Younis, FM ;
Kariya, K ;
Otto, VI ;
Lenzlinger, PM ;
Grosjean, MB ;
Eugster, HP ;
Trentz, O ;
Kossmann, T ;
Morganti-Kossmann, MC .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (02) :369-380
[55]  
Stroemer RP, 1997, J CEREBR BLOOD F MET, V17, P597
[56]   EARLY INTRATHECAL PRODUCTION OF INTERLEUKIN-6 PREDICTS THE SIZE OF BRAIN LESION IN STROKE [J].
TARKOWSKI, E ;
ROSENGREN, L ;
BLOMSTRAND, C ;
WIKKELSO, C ;
JENSEN, C ;
EKHOLM, S ;
TARKOWSKI, A .
STROKE, 1995, 26 (08) :1393-1398
[57]   Potential mechanisms of interleukin-1 involvement in cerebral ischaemia [J].
Touzani, O ;
Boutin, H ;
Chuquet, J ;
Rothwell, N .
JOURNAL OF NEUROIMMUNOLOGY, 1999, 100 (1-2) :203-215
[58]   Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats [J].
Wang, XK ;
Barone, FC ;
Aiyar, NV ;
Feuerstein, GZ .
STROKE, 1997, 28 (01) :155-161
[59]   CONCOMITANT CORTICAL EXPRESSION OF TNF-ALPHA AND IL-1-BETA MESSENGER-RNAS FOLLOWS EARLY RESPONSE GENE-EXPRESSION IN TRANSIENT FOCAL ISCHEMIA [J].
WANG, XK ;
YUE, TL ;
BARONE, FC ;
WHITE, RF ;
GAGNON, RC ;
FEUERSTEIN, GZ .
MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1994, 23 (2-3) :103-114
[60]  
Weir B, 1999, ACT NEUR S, V72, P27