Selection at Linked Sites Shapes Heritable Phenotypic Variation in C. elegans

被引：178

作者：

Rockman, Matthew V. ^{[1
,2
,3
,4
]}

Skrovanek, Sonja S. ^{[3
,4
,5
]}

Kruglyak, Leonid ^{[3
,4
,5
]}

机构：

[1] NYU, Dept Biol, New York, NY 10003 USA

[2] NYU, Ctr Genom & Syst Biol, New York, NY 10003 USA

[3] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[4] Princeton Univ, Dept Ecol & Evolutionary Biol, Carl Icahn Lab, Princeton, NJ 08544 USA

[5] Princeton Univ, Howard Hughes Med Inst, Princeton, NJ 08544 USA

来源：

SCIENCE | 2010年 / 330卷 / 6002期

关键词：

GENE-EXPRESSION; NATURAL-SELECTION; DNA POLYMORPHISM; EVOLUTION; GENOME; RECOMBINATION; CONSEQUENCES; MUTATION; TRAITS;

D O I：

10.1126/science.1194208

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutation generates the heritable variation that genetic drift and natural selection shape. In classical quantitative genetic models, drift is a function of the effective population size and acts uniformly across traits, whereas mutation and selection act trait-specifically. We identified thousands of quantitative trait loci (QTLs) influencing transcript abundance traits in a cross of two Caenorhabditis elegans strains; although trait-specific mutation and selection explained some of the observed pattern of QTL distribution, the pattern was better explained by trait-independent variation in the intensity of selection on linked sites. Our results suggest that traits in C. elegans exhibit different levels of variation less because of their own attributes than because of differences in the effective population sizes of the genomic regions harboring their underlying loci.

引用

页码：372 / 376

页数：5