Some aspects of the etiology of non-Hodgkin's lymphoma

被引:22
作者
Hardell, L [1 ]
Lindström, G
van Bavel, B
Fredrikson, M
Liljegren, G
机构
[1] Orebro Med Ctr, Dept Oncol, S-70185 Orebro, Sweden
[2] Umea Univ, Inst Environm Chem, S-90187 Umea, Sweden
[3] Linkoping Univ Hosp, Dept Occupat & Environm Med, S-58185 Linkoping, Sweden
[4] Orebro Med Ctr, Dept Surg, Orebro, Sweden
关键词
non-Hodgkin's lymphoma; etiology; phenoxyacetic acids; chlorophenols; dioxins; organic solvents; polychlorinated biphenyls; chlordanes; viruses; immunosuppression;
D O I
10.2307/3433819
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
in epidemiologic studies, non-Hodgkin's lymphoma (NHL) has been associated with exposure to chemicals such as phenoxyacetic acids; chlorophenols; dioxins; organic solvents including benzene, polychlorinated biphenyls, chlordanes; and immunosuppressive drugs. Experimental evidence and clinical observations indicate that these chemicals may impair the immune system. The risk is increased for NHL in persons with acquired and congenital immune deficiency as well as autoimmune disorders. Also, certain viruses have been suggested to be of etiologic significance for NHL. In some cases of NHL the common mechanism for ail these agents and conditions may be immunosuppression, possibly in combination with viruses.
引用
收藏
页码:679 / 681
页数:3
相关论文
共 44 条
[1]   CANCER MORBIDITY IN BLOOD RECIPIENTS - RESULTS OF A COHORT STUDY [J].
BLOMBERG, J ;
MOLLER, T ;
OLSSON, H ;
ANDERSON, H ;
JONSSON, M .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (15) :2101-2105
[2]  
Cruz P D Jr, 1994, Adv Dermatol, V9, P79
[3]   IMPAIRED IN-VITRO LYMPHOCYTE-RESPONSES IN PATIENTS WITH ELEVATED PENTACHLOROPHENOL (PCP) BLOOD-LEVELS [J].
DANIEL, V ;
HUBER, W ;
BAUER, K ;
OPELZ, G .
ARCHIVES OF ENVIRONMENTAL HEALTH, 1995, 50 (04) :287-292
[4]  
EXON JH, 1985, INT J IMMUNOPHARMACO, V7, P239
[5]   Immunological changes among farmers exposed to phenoxy herbicides: Preliminary observations [J].
Faustini, A ;
Settimi, L ;
Pacifici, R ;
Fano, V ;
Zuccaro, P ;
Forastiere, F .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1996, 53 (09) :583-585
[6]   Residential and occupational exposure to sunlight and mortality from non-Hodgkin's lymphoma: Composite (threefold) case-control study [J].
Freedman, DM ;
Zahm, SH ;
Dosemeci, M .
BRITISH MEDICAL JOURNAL, 1997, 314 (7092) :1451-1455
[7]  
Hardell L, 1996, INT J ONCOL, V9, P1139
[8]  
HARDELL L, 1994, CANCER RES, V54, P2386
[9]   MALIGNANT-LYMPHOMA AND EXPOSURE TO CHEMICALS, ESPECIALLY ORGANIC-SOLVENTS, CHLOROPHENOLS AND PHENOXY ACIDS - A CASE-CONTROL STUDY [J].
HARDELL, L ;
ERIKSSON, M ;
LENNER, P ;
LUNDGREN, E .
BRITISH JOURNAL OF CANCER, 1981, 43 (02) :169-176
[10]  
Hardell L, 1996, INT J ONCOL, V9, P603