No association of germline alteration of MSR1 with prostate cancer risk

被引：40

作者：

Wang, L

McDonnell, SK

Cunningham, JM

Hebbring, S

Jacobsen, SJ

Cerhan, JR

Slager, SL

Blute, ML

Schaid, DJ

Thibodeau, SN

机构：

[1] Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Div Expt Pathol, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Fdn, Dept Urol, Rochester, MN 55905 USA

来源：

NATURE GENETICS | 2003年 / 35卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ng1239

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.

引用

页码：128 / 129

页数：2

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