Memory decline of aging reduced by extracellular superoxide dismutase overexpression

被引:22
作者
Levin, ED
Christopher, NC
Crapo, JD
机构
[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA
[2] Natl Jewish Med & Res Ctr, Denver, CO USA
关键词
aging; extracellular superoxide dismutase (EC-SOD); memory; radial-arm maze;
D O I
10.1007/s10519-004-1510-y
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Extracellular superoxide dismutase (EC-SOD) plays an important role in controlling oxidative stress as well as intercellular signaling. In the current study, we tested the effect of EC-SOD overexpression over the lifespan of a set of mice and their wild-type controls to determine the time scale over which EC-SOD overexpression might attenuate aging-induced memory impairment. Mice with overexpression of EC-SOD and wild-type controls were initially trained on the radial-arm maze as young adults (3-5 months) and then retrained during middle age (12-14 months) and retested in old age at 27 and 30 months. There was little EC-SOD effect during the young adult middle age periods. EC-SOD overexpression prevented the decline in choice accuracy when the mice were 27-30 months of age. The EC-SOD overexpressing mice maintained their performance, while the wild-type mice declined to naive levels of performance by 30 months of age. Enhancement of EC-SOD activity appears to improve memory performance specifically in aging mice. EC-SOD mimetic treatment during the course of aging may hold promise for aging-induced cognitive impairment.
引用
收藏
页码:447 / 453
页数:7
相关论文
共 25 条
  • [21] Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse
    Sheng, HX
    Brady, TC
    Pearlstein, RD
    Crapo, JD
    Warner, DS
    [J]. NEUROSCIENCE LETTERS, 1999, 267 (01) : 13 - 16
  • [22] Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid
    Singh, A
    Naidu, PS
    Kulkarni, SK
    [J]. FREE RADICAL RESEARCH, 2003, 37 (11) : 1245 - 1252
  • [23] Oxidative stress in Alzheimer's disease
    Smith, MA
    Rottkamp, CA
    Nunomura, A
    Raina, AK
    Perry, G
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2000, 1502 (01): : 139 - 144
  • [24] Thiels E, 2000, J NEUROSCI, V20, P7631
  • [25] Wilkinson D, 2001, INT J CLIN PRACT, V55, P129