Synthesis of a tumor-associated 2,3-sialyl-T glycododecapeptide antigen from the tandem repeat region of the mucin MUC1

被引：23

作者：

Dziadek, S ^{[1
]}

Kunz, H ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

来源：

SYNLETT | 2003年 / 11期

关键词：

2,3-sialyl-T antigen; glycopeptides; MUC; 1; regioselective sialylation; solid-phase synthesis;

D O I：

10.1055/s-2003-41009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a cell surface antigen for the development of selective antitumor vaccines, a tumor-associated glycododecapeptide from epithelial MUC1 carrying the 2,3-sialyl-T antigen was synthesized. The 2,3-ST building block was assembled from a T-N-threonine conjugate by stepwise saccharide chain extension and utilized for the solid-phase glycopeptide synthesis on the fluoride-labile PTMSEL linker.

引用

页码：1623 / 1626

页数：4

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