共 46 条
AIK-C measles vaccine expressing fusion protein of respiratory syncytial virus induces protective antibodies in cotton rats
被引:23
作者:

Sawada, Akihito
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h-index: 0
机构:
Kitasato Univ, Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088641, Japan Kitasato Univ, Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088641, Japan

Komase, Katsuhiro
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h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Tokyo 2080011, Japan Kitasato Univ, Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088641, Japan

Nakayama, Tetsuo
论文数: 0 引用数: 0
h-index: 0
机构:
Kitasato Univ, Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088641, Japan Kitasato Univ, Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088641, Japan
机构:
[1] Kitasato Univ, Kitasato Inst Life Sci, Lab Viral Infect 1, Minato Ku, Tokyo 1088641, Japan
[2] Natl Inst Infect Dis, Dept Virol 3, Tokyo 2080011, Japan
来源:
关键词:
Measles virus (MV);
Respiratory syncytial virus (RSV);
Cotton rat;
Neutralizing antibodies;
IMMUNE-RESPONSES;
YOUNG-CHILDREN;
CONFERS PROTECTION;
CLONED CDNA;
INFANTS;
RSV;
INFECTION;
STRAIN;
LIVE;
GLYCOPROTEIN;
D O I:
10.1016/j.vaccine.2010.12.028
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Respiratory syncytial virus (RSV) is the most common cause of respiratory infection in infants, and no vaccine is available. In this report, recombinant AIK-C measles vaccines, expressing the RSV G or F protein of subgroup A (MVAIK/RSV/G or F), were investigated as a RSV vaccine candidate. MVAIK/RSV/G or F had the original ts phenotype and expressed RSV/G or F protein. Cross-reactive neutralizing antibodies against RSV subgroups A and B were detected in cotton rats immunized intramuscularly with MVAIK/RSV/F but not MVAIK/RSV/G. In cotton rats infected with RSV, RSV was recovered and lung histopathological finding was compatible with interstitial pneumonia, demonstrating thickening of alveolar walls and infiltration of mononuclear cells. When cotton rats immunized with MVAIK/RSV/F were challenged with homologous RSV subgroup A. no infectious RSV was recovered and very mild inflammation was noted without RSV antigen expression. When they were challenged with subgroup B, protective efficacy decreased. When cotton rats immunized with MVAIK/RSV/G were challenged with RSV subgroup A, low levels of infectious virus were recovered from lung. When challenged with subgroup B, no protective effects was demonstrated, demonstrating large amounts of RSV antigen in bronchial-epithelial cells. MVAIK/RSV/F is promising candidate and protective effects should be confirmed in monkey model. (C) 2010 Elsevier Ltd. All rights reserved.
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页码:1481 / 1490
页数:10
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