Engineering human chromosomes for gene therapy studies

被引：10

作者：

Choo, KHA ^{[1
]}

机构：

[1] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic 3052, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 06期

关键词：

D O I：

10.1016/S1471-4914(01)01951-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We now have the capability to engineer human chromosomes that could be used to deliver therapeutic genes in gene therapy studies. These vectors have the advantages of being non-disruptive to the genome, non-immunogenic and are capable of carrying very large genes with all their regulatory sequences. What challenges lie ahead, and what future does this technology hold for gene therapy?

引用

页码：235 / 237

页数：3

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