New molecular approaches for identifying novel targets, mechanisms, and biomarkers for prostate cancer chemopreventive agents

被引：9

作者：

Williams, ED

Brooks, JD

机构：

[1] Stanford Univ, Med Ctr, Dept Urol, Stanford, CA 94305 USA

[2] St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia

来源：

UROLOGY | 2001年 / 57卷 / 4A期

关键词：

D O I：

10.1016/S0090-4295(00)00951-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recently developed complementary DNA (cDNA) microarray technology allows simultaneous assessment of expression on many hundreds or thousands of genes simultaneously, This technology holds great promise for providing new insights into prostate carcinogenesis that will reveal new targets for preventive intervention strategies. In addition, this technology will deepen understanding of the means by which putative preventive compounds exert their effects, generating molecular genetic biomarkers of treatment efficacy. Several putative preventive agents are currently under investigation, and development of navel preventive strategies poses significant challenges. High throughput approaches, such as cDNA microarrays, will speed discovery and progress in prostate cancer chemoprevention. (C) 2001, Elsevier Science Inc.

引用

页码：100 / 102

页数：3

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