Aziridination of alkenes using 3-acetoxyamino-2-trifluoromethylquinazolin-4(3H)-one

被引：19

作者：

Atkinson, RS ^{[1
]}

Coogan, MP ^{[1
]}

Cornell, CL ^{[1
]}

机构：

[1] AGREVO LTD,SAFFRON WALDEN CB10 1XL,ESSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 02期

关键词：

D O I：

10.1039/p19960000157

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of 3-amino-2-trifluoromethylquinazolin-4(3H)-one 6 with lead tetraacetate in dichloromethane gives the title 3-acetoxyamino derivative 7 which is isolable at room temperature and considerably more stable than the corresponding 2-alkyl substituted analogues. Compound 7 aziridinates alkenes in yields which are consistently higher than those from the 2-alkyl substituted analogues. Aziridinations using 3-acetoxyaminoquinazolinones bearing other electron-withdrawing groups on the 2-position of the quinazolinone ring have been examined.

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收藏

页码：157 / 166

页数：10

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