Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity

被引：30

作者：

Endsley, Janice J. ^{[1
]}

Hogg, Alison ^{[2
]}

Shell, Lis J. ^{[1
]}

McAulay, Martin ^{[2
]}

Coffey, Tracey ^{[2
]}

Howard, Chris ^{[2
]}

Scherer, Charles F. Capinos ^{[1
]}

Waters, W. Ray ^{[3
]}

Nonnecke, Brian ^{[3
]}

Estes, D. Mark ^{[1
]}

Villarreal-Ramos, Bernardo ^{[2
]}

机构：

[1] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Dept Pediat, Galveston, TX 77555 USA

[2] Inst Anim Hlth, Newbury RG20 7NN, Berks, England

[3] USDA ARS, Natl Anim Dis Ctr, Ames, IA 50010 USA

来源：

VACCINE | 2007年 / 25卷 / 50期

基金：

英国生物技术与生命科学研究理事会;

关键词：

cytotoxicity; tuberculosis; CD4(+) T cells;

D O I：

10.1016/j.vaccine.2007.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effector mechanisms used by CD4(+) T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4(+) T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guerin (BCG). Antigenic stimulation of peripheral blood CD4(+) T cells from BCG-vaccinated cattle enhanced expression of perforin and IFN gamma in cells expressing a CD45RA(-)CD45RO(+)CD62L(+) cell surface phenotype, enhanced transcription of granulysin, IFN gamma, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4(+) T cells against BCG-infected macrophages. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8384 / 8394

页数：11

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