DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification

被引：42

作者：

Buryanov, YI ^{[1
]}

Shevchuk, TV ^{[1
]}

机构：

[1] Russian Acad Sci, Pushchino Branch, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Pushchino 142290, Moscow Region, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2005年 / 70卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

DNA; methylation; DNA methyltransferases; CpG; CpNpG; and CpNpN sequences; structure; functions; eukaryotes;

D O I：

10.1007/s10541-005-0178-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.

引用

页码：730 / 742

页数：13

共 163 条

[1] Epigenetic modifications affect Dnmt3L expression [J].

Aapola, U ;

Mäenpää, K ;

Kaipia, A ;

Peterson, P .

BIOCHEMICAL JOURNAL, 2004, 380 :705-713

[2] Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity [J].

Aapola, U ;

Liiv, I ;

Peterson, P .

NUCLEIC ACIDS RESEARCH, 2002, 30 (16) :3602-3608

[3] UNMETHYLATED CPG ISLANDS ASSOCIATED WITH GENES IN HIGHER-PLANT DNA [J].

ANTEQUERA, F ;

BIRD, AP .

EMBO JOURNAL, 1988, 7 (08) :2295-2299

[4] NUMBER OF CPG ISLANDS AND GENES IN HUMAN AND MOUSE [J].

ANTEQUERA, F ;

BIRD, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11995-11999

[5] RNA-directed DNA methylation in Arabidopsis [J].

Aufsatz, W ;

Mette, MF ;

van der Winden, J ;

Matzke, AJM ;

Matzke, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 :16499-16506

[6] Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin [J].

Bachman, KE ;

Rountree, MR ;

Baylin, SB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) :32282-32287

[7] METHYLATION INDUCED PREMEIOTICALLY IN ASCOBOLUS - COEXTENSION WITH DNA REPEAT LENGTHS AND EFFECT ON TRANSCRIPT ELONGATION [J].

BARRY, C ;

FAUGERON, G ;

ROSSIGNOL, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4557-4561

[8]

Baylin SB, 1998, ADV CANCER RES, V72, P141

[9]

BERDYSHEV TD, 1967, BIOKHIMIYA, V32, P988

[10] Carrot DNA-methyltransferase is encoded by two classes of genes with differing patterns of expression [J].

Bernacchia, G ;

Primo, A ;

Giorgetti, L ;

Pitto, L ;

Cella, R .

PLANT JOURNAL, 1998, 13 (03) :317-329

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