Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats

被引：69

作者：

Yang, Lan ^{[1
]}

Wang, Cheng-zhang ^{[1
]}

Ye, Jian-zhong ^{[1
]}

Li, Hai-tao ^{[2
]}

机构：

[1] CAF, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China

[2] Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Ginkgo biloba; Polyprenols; Essentiale; Hepatoprotective; Antioxidant; CARBON-TETRACHLORIDE; RIFAMPICIN;

D O I：

10.1016/j.fitote.2011.04.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hepatoprotective effects of polyprenols from Ginkgo biloba L leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：834 / 840

页数：7

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