Dehydroepiandrosterone replacement therapy - panacea, snake oil, or a bit of both?

被引:2
作者
Chang, Alice Y. [1 ]
Ghayee, Hans K. [1 ]
Auchus, Richard J. [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Div Endocrinol & Metab, Dallas, TX 75390 USA
来源
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM | 2008年 / 4卷 / 08期
关键词
D O I
10.1038/ncpendmet0870
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Age-related declines in dehydroepiandrosterone sulfate concentration parallel the physical and cognitive changes of aging. This observation suggests that these events are causally related and that replacement therapy might have beneficial effects in the elderly. The authors of this Viewpoint consider the evidence for, and against, such an approach.
引用
收藏
页码:442 / 443
页数:2
相关论文
共 10 条
[1]   Dehydroepiandrosterone replacement in women with adrenal insufficiency [J].
Arlt, W ;
Callies, F ;
van Vlijmen, JC ;
Koehler, I ;
Reincke, M ;
Bidlingmaier, M ;
Huebler, D ;
Oettel, M ;
Ernst, M ;
Schulte, HM ;
Allolio, B .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (14) :1013-1020
[2]   A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE [J].
BARRETTCONNOR, E ;
KHAW, KT ;
YEN, SSC .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (24) :1519-1524
[3]   Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids [J].
Baulieu, EE ;
Robel, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4089-4091
[4]   Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study [J].
Berr, C ;
Lafont, S ;
Debuire, B ;
Dartigues, JF ;
Baulieu, EE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13410-13415
[5]   Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women [J].
Igwebuike, Ada ;
Irving, Brian A. ;
Bigelow, Maureen L. ;
Short, Kevin R. ;
McConnell, Joseph P. ;
Nair, K. Sreekumaran .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (02) :534-538
[6]   Replacement of dehydroepiandrosterone in adrenal failure:: No benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial [J].
Lovås, K ;
Gebre-Medhin, G ;
Trovik, TS ;
Fougner, KJ ;
Uhlving, S ;
Nedrebo, BG ;
Myking, OL ;
Kämpe, O ;
Husebye, ES .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (03) :1112-1118
[7]   Effects of testosterone replacement in androgen-deficient women with hypopituitarism: A randomized, double-blind, placebo-controlled study [J].
Miller, KK ;
Biller, BMK ;
Beauregard, C ;
Lipman, JG ;
Jones, J ;
Schoenfeld, D ;
Sherman, JC ;
Swearingen, B ;
Loeffler, J ;
Klibanski, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (05) :1683-1690
[8]   EFFECTS OF REPLACEMENT DOSE OF DEHYDROEPIANDROSTERONE IN MEN AND WOMEN OF ADVANCING AGE [J].
MORALES, AJ ;
NOLAN, JJ ;
NELSON, JC ;
YEN, SSC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (06) :1360-1367
[9]   DHEA in elderly women and DHEA or testosterone in elderly men [J].
Nair, K. Sreekumaran ;
Rizza, Robert A. ;
O'Brien, Peter ;
Dhatariya, Ketan ;
Short, Kevin R. ;
Nehra, Ajay ;
Vittone, Janet L. ;
Klee, George G. ;
Basu, Ananda ;
Basu, Rita ;
Cobelli, Claudio ;
Toffolo, Gianna ;
Dalla Man, Chiara ;
Tindall, Donald J. ;
Melton, L. Joseph, III ;
Smith, Glenn E. ;
Khosla, Sundeep ;
Jensen, Michael D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (16) :1647-1659
[10]   Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: A randomized, placebo-controlled, cross-over trial [J].
van Thiel, SW ;
Romijn, JA ;
Pereira, AM ;
Biermasz, NR ;
Roelfsema, F ;
van Hemert, A ;
Ballieux, B ;
Smit, JWA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) :3295-3303