Systems chemistry: Kinetic and computational analysis of a nearly exponential organic replicator

被引：121

作者：

Kindermann, M ^{[1
]}

Stahl, I ^{[1
]}

Reimold, M ^{[1
]}

Pankau, WM ^{[1
]}

von Kiedrowski, G ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Lehrstuhl Organ Chem 1, D-44780 Bochum, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 41期

关键词：

chirality; computer chemistry; molecular modeling; supramolecular chemistry; template synthesis;

D O I：

10.1002/anie.200501527

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combining kinetic, structural, and computational studies on complex dynamic feedback systems may lead to the field of systems chemistry". The approach is exemplified by the analysis of a simple organic self-replicating system that has the potential to express both homochiral autocatalysis and heterochiral cross-catalysis (see picture). (Figure Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：6750 / 6755

页数：6

共 24 条

[1] Transfer of stereochemical information in a minimal self-replicating system [J].

Allen, VC ;

Philp, D ;

Spencer, N .

ORGANIC LETTERS, 2001, 3 (05) :777-780

[2] ENANTIOSELECTIVE PREPARATION OF 1,3-CYCLOHEXADIENE AND 1,4-CYCLOHEPTADIENE DERIVATIVES - SYNTHESIS OF (PLUS)-DICTYOPTERENE C' [J].

ASAOKA, M ;

KOBAYASHI, K ;

TAKEI, H .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1994, 67 (04) :1141-1146

[3]

BAECKVALL JE, 1993, SYNTHESIS-STUTTGART, V343, P642

[4] Asymmetric autocatalysis and its implications for the origin of homochirality [J].

Blackmond, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) :5732-5736

[5] ON SPONTANEOUS ASYMMETRIC SYNTHESIS [J].

FRANK, FC .

BIOCHIMICA ET BIOPHYSICA ACTA, 1953, 11 (04) :459-463

[6] MOLECULAR RECOGNITION - A REMARKABLY SIMPLE RECEPTOR FOR THE SELECTIVE COMPLEXATION OF DICARBOXYLIC-ACIDS [J].

GARCIATELLADO, F ;

GOSWAMI, S ;

CHANG, SK ;

GEIB, SJ ;

HAMILTON, AD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (20) :7393-7394

[7] Approaching exponential growth with a self-replicating peptide [J].

Issac, R ;

Chmielewski, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (24) :6808-6809

[8] An enantioselective route to paeonilactone A via palladium- and copper-catalyzed reactions [J].

Jonasson, C ;

Rönn, M ;

Bäckvall, JE .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (07) :2122-2126

[9] Self-replication vs. reactive binary complexes -: manipulating recognition-mediated cycloadditions by simple structural modifications [J].

Pearson, RJ ;

Kassianidis, E ;

Slawin, AMZ ;

Philp, D .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (23) :3434-3441

[10] A chiroselective peptide replicator [J].

Saghatelian, A ;

Yokobayashi, Y ;

Soltani, K ;

Ghadiri, MR .

NATURE, 2001, 409 (6822) :797-801

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