Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array

被引：92

作者：

Bajaj, Avinash ^{[1
]}

Rana, Subinoy ^{[1
]}

Miranda, Oscar R. ^{[1
]}

Yawe, Joseph C. ^{[1
]}

Jerry, D. Joseph ^{[2
]}

Bunz, Uwe H. F. ^{[3
]}

Rotello, Vincent M. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

[3] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

CHEMICAL SCIENCE | 2010年 / 1卷 / 01期

关键词：

SENSOR ARRAY; COLORIMETRIC IDENTIFICATION; PROTEINS;

D O I：

10.1039/c0sc00165a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticle-green fluorescent protein (NP-GFP) based arrays have been created for rapid identification of mammalian cells on the basis of cell surface properties. Highly reproducible characteristic patterns were obtained from different cell types enabling the identification of cell types and cancer states. Using these arrays we could differentiate between isogenic normal, cancer and metastatic cell types using only similar to 5000 cells.

引用

页码：134 / 138

页数：5

共 38 条

[1] Monolayer-protected clusters with fluorescent dansyl ligands [J].

Aguila, A ;

Murray, RW .

LANGMUIR, 2000, 16 (14) :5949-5954

[2]

Alberts B., 2002, The shape and structure of proteins, Vfourth, DOI 10.1093/aob/mcg023

[3] Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays [J].

Bajaj, Avinash ;

Miranda, Oscar R. ;

Kim, Ik-Bum ;

Phillips, Ronnie L. ;

Jerry, D. Joseph ;

Bunz, Uwe H. F. ;

Rotello, Vincent M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (27) :10912-10916

[4] Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain [J].

Blackburn, AC ;

McLary, SC ;

Naeem, R ;

Luszcz, J ;

Stockton, DW ;

Donehower, LA ;

Mohammed, M ;

Mailhes, JB ;

Soferr, T ;

Naber, SP ;

Otis, CN ;

Jerry, DJ .

CANCER RESEARCH, 2004, 64 (15) :5140-5147

[5] Antibody microarray-based oncoproteomics [J].

Borrebaeck, Carl A. K. .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2006, 6 (08) :833-838

[6] A chemosensor array for the colorimetric identification of 20 natural amino acids [J].

Buryak, A ;

Severin, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (11) :3700-3701

[7]

De M, 2009, NAT CHEM, V1, P461, DOI [10.1038/NCHEM.334, 10.1038/nchem.334]

[8] Nickel-Ion-Mediated Control of the Stoichiometry of His-Tagged Protein/Nanoparticle Interactions [J].

De, Mrinmoy ;

Rana, Subinoy ;

Rotello, Vincent M. .

MACROMOLECULAR BIOSCIENCE, 2009, 9 (02) :174-178

[9] Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dβ cell line [J].

Deugnier, Marie-Ange ;

Faraldo, Marisa M. ;

Teuliere, Jerome ;

Thiery, Jean Paul ;

Medina, Daniel ;

Glukhova, Marina A. .

DEVELOPMENTAL BIOLOGY, 2006, 293 (02) :414-425

[10] Pattern-based discrimination of enantiomeric and structurally similar amino acids: An optical mimic of the mammalian taste response [J].

Folmer-Andersen, JF ;

Kitamura, M ;

Anslyn, EV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (17) :5652-5653

← 1 2 3 4 →